Domain List
Name Description
14_3_3 14-3-3 homologues
4.1m putative band 4.1 homologues binding motif
A4_EXTRA amyloid A4
ACTIN ACTIN
ADF Acting depolymerisation factor/cofilin -like domains
AHL archael histon and TFs (euk.)
ALBUMIN ALBUMIN
ANATO Anaphylatoxin homologous domain
ANK ankyrin repeats
ANX Annexin repeats
APPLE APPLE domain
ARF ARF-like small GTPases; ARF, ADP-ribosylation factor
ARM Armadillo/beta-catenin-like repeats
ArfGap Putative GTP-ase activating proteins for the small GTPase, Arf
AspPc AspPc
B41 Band 4.1 homologues
BAG BAG domains
BAH Bromo adjacent homology domain
BBOX zinc finger
BCL (BH1, BH2, (BCL (B-Cell lymphoma)
BH4 BH4 Bcl-2 homology region 4
BIR Baculoviral inhibition of apoptosis protein repeat
BPI1 BPI/LBP/CETP N-terminal domain
BPI2 BPI/LBP/CETP C-terminal domain
BRCT breast cancer carboxy-terminal domain
BRLZ basic region leucin zipper
BROMO BROMO
BTB Broad-Complex, Tramtrack and Bric a brac
BTK BTK motif
B_lectin Bulb-type mannose-specific lectin
BowB Bowman-Birk type proteinase inhibitor
C1 Protein kinase C conserved region 1 (C1) domains
(Cysteine-rich domains)
C1Q C1q domain.
C2 Protein kinase C conserved region 2 (CalB)
C4 C-terminal tandem repeated domain in type 4 procollagens
CA Cadherin repeats.
CAD Domains present in proteins implicated in post-mortem DNA
fragmentation
CALCITONIN calcitonin
CARD Caspase recruitment domain
CASc Caspase, interleukin-1 beta converting enzyme (ICE) homologues
CBS Domain in cystathionine beta-synthase and other proteins.
CCP Domain abundant in complement control proteins; SUSHI repeat;
short complement-like repeat (SCR)
CH Calponin homology domain
CHROMO Chromatin organization modifier domain
CLECT C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
CLH Clathrin heavy chain repeat homology
CLUSTERIN_ALPHA CLUSTERIN alpha chain
CLUSTERIN_BETA CLUSTERIN Beta chain
CNH Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
CNX Connexin homologues
COLFI Fibrillar collagens C-terminal domain
COLIPASE COLIPASE
CRF corticotropin-releasing factor
CSF2 Granulocyte-macrophage colony-simulating factor (GM-CSF)
CSP Cold shock protein domain
CT C-terminal cystine knot-like domain (CTCK)
CUB Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
CULLIN Cullin
CY Cystatin-like domain
CYCc Adenylyl- / guanylyl cyclase, catalytic domain
Calx_beta Na-Ca exchangers and integrin
ChSh Chromo Shadow Domain
CheW Two component signalling adaptor domain
ChtBD Chitin binding domain
CysPc Calpain-like thiol protease family.
DAGKa Diacylglycerol kinase accessory domain (presumed)
DAGKc Diacylglycerol kinase catalytic domain (presumed)
DAX Domain present in Dishevelled andaxin
DEATH DEATH domain, found in protein, involved in cell death (apoptosis).
DED DED
DEFSN Defensin/corticostatin family
DEP Domain found in Dishevelled, Egl-10, and Pleckstrin
DISIN Homologues of snake disintegrins
DM Doublesex DNA-binding motif
DSL delta serrate ligand
DSPc Dual specificity phosphatase, catalytic domain
DSRM Double-stranded RNA binding motif
DUF1 Domain of Unknown Function with GGDEF motif
DUF2 Domain of Unknown Function 2
DYNc Dynamin, GTPase
DnaJ DnaJ molecular chaperone homology domain
EFh EF-hand, calcium binding motif
EGF Epidermal growth factor-like domain.
EGF_CA Calcium-binding EGF-like domain
EGF_Lam Laminin-type epidermal growth factor-like domain
EGF_like EGF domain, unclasssified subfamily
EH Eps15 homology domain
END Endothelin
ENTH Epsin N-terminal homology (ENTH) domain
EPENDYMIN EPENDYMIN
FA58C Coagulation factor 5/8 C-terminal domain, discoidin domain
FBG Fibrinogen-related domains (FReDs)
FBOX A Receptor for Ubiquitination Targets
FCH Fes/CIP4 homology domain
FGF Acidic and basic fibroblast growth factor family.
FH FORKHEAD
FHA Forkhead associated domain
FIMAC FIMAC
FN1 Fibronectin type 1 domain
FN2 Fibronectin type 2 domain
FN3 Fibronectin type 3 domain
FOLLI FOLL
FOLN Follistatin-N-terminal domain-like
FRI Frizzled
FU Furin-like repeats
FYVE Protein present in Fab1, YOTB, Vac1, and EEA1
G-alpha G protein alpha subunit
GAF Domain present in phytochromes and cGMP-specific phosphodiesterases.
GAL4 GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
GAS2 GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
GASTRIN gastrin / cholecystokinin / caerulein family
GED Dynamin GTPase effector domain
GEL Gelsolin homology domain
GGL G protein gamma subunit-like motifs
GHA Glycoprotein hormone alpha chain homologues.
GHB Glycoprotein hormone beta chain homologues.
GLA Domain containing Gla (gamma-carboxyglutamate) residues.
GLECT Galectin
GLUCAGON GLUCAGON
GPS G-protein-coupled receptor proteolytic site domain
GRAN Granulin
Galanin Galanin
GuKc Guanylate kinase homologues.
HALZ homeobox associated leucine zipper
HAMP HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins,
Phosphatases) domain
HECTc Domain Homologous to E6-AP Carboxyl Terminus with E3 ubiquitin-protein
ligases. Can bind to E2 enzymes.
HLH helix loop helix domain
HPT HPT
HR1 Protein kinase C-related kinase homology region 1 homologues
HRDC Helicase and RNase D C-terminal
HTH_ARAC helix_turn_helix, arabinose operon control protein
HTH_ASNC helix_turn_helix ASNC type
HTH_GNTR helix_turn_helix gluconate operon transcriptional repressor
HTH_ICLR helix_turn_helix isocitrate lyase regulation
HTH_LACI helix_turn _helix lactose operon repressor
HTH_MARR helix_turn_helix multiple antibiotic resistance protein
HX Hemopexin-like repeats.
HYDROPHOBIN Hydrophobin
HhH1 Helix-hairpin-helix DNA-binding motif class 1
HhH2 Helix-hairpin-helix class 2 (Pol1 family) motifs
HintC Hint (Hedgehog/Intein) domain C-terminal region
HintN Hint (Hedgehog/Intein) domain N-terminal region
HisKc Histidine kinases
HisKc_like HisKc_like
HormR Domain present in hormone receptors
IB Insulin growth factor-binding protein homologues
IG_like Immunoglobulin Superfamily
IGc1 Immunoglobulin C-Type
IGc2 Immunoglobulin C-2Type
IGv Immunoglobulin V-Type
IL1 Interleukin-1 homologues
IL6 Interleukin-6 homologues
IL7 Interleukin-7 and interleukin-9 family.
ILWEQ I/LWEQ domain
INB Integrin beta subunits (N-terminal portion of extracellular region)
INTERFERON_A_B_D Interferon alpha, beta and delta.
INTERLEUKIN_10 Interleukin-10 family
INTERLEUKIN_2 Interleukin-2 family
INTERLEUKIN_4_13 Interleukins 4 and 13
IPPc Inositol polyphosphate phosphatase, catalytic domain homologues
IQ Short calmodulin-binding motif containing conserved Ile and Gln
IRF interferon regulatory factor
ITAM Immunoreceptor tyrosine-based activation motif
IlGF Insulin / insulin-like growth factor / relaxin family.
Int_alpha Integrin alpha (beta-propellor repeats).
JAB_MPN JAB/MPN domain
KAZAL Kazal type serine protease inhibitors
KH K homology RNA-binding domain
KISc Kinesin motor, catalytic domain. ATPase.
KR Kringle domain
KRAB krueppel associated box
KU BPTI/Kunitz family of serine protease inhibitors.
LDLa Low-density lipoprotein receptor domain class A
LH2 Lipoxygenase homology 2 (beta barrel) domain
LIF_OSM leukemia inhibitory factor
LIM Zinc-binding domain present in Lin-11, Isl-1, Mec-3.
LINK Link (Hyaluronan-binding)
LMWPc Low molecular weight phosphatase family
LRR Leucine-rich repeats, outliers
LRRCT Leucine rich repeat C-terminal domain
LRRNT Leucine rich repeat N-terminal domain
LRR_BAC Leucine-rich repeats, bacterial type
LRR_CC Leucine-rich repeat, CC (cysteine-containing) subfamily
LRR_PS Leucine-rich repeat, plant-specific subfamily
LRR_RI Leucine rich repeat, ribonuclease inhibitor type
LRR_SD22 Leucine-rich repeat, SDS22-like subfamily
LRR_TYP Leucine-rich repeats, typical (most populated) subfamily
LU Ly-6 antigen / uPA receptor -like domain
LY Low-density lipoprotein-receptor YWTD domain
LYZ1 Alpha-lactalbumin / lysozyme C
LYZ2 Lysozyme subfamily 2
LamB Laminin B domain
LamG Laminin G domain
LamNT Laminin N-terminal domain (domain VI)
LysM Lysin motif
MA Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
MACPF MAC_PERFORIN
MAM Domain in meprin, A5, receptor protein tyrosine phosphatase mu
(and others)
MATH meprin and TRAF homology
MCM minichromosome maintenance proteins
MYELIN_PLP_2 Myelin proteolipid protein (PLP or lipophilin)
MYSc Myosin. Large ATPases.
MeTrc Methyltransferase, chemotaxis proteins
MyTH4 Domain in Myosin and Kinesin Tails
NATRIURETIC_PEPTIDE Natriuretic peptide
NGF Nerve growth factor (NGF or beta-NGF)
NH Neurohypophysial hormones
NL NL
NMU Neuromedin U
Nebulin Nebulin
OLF Olfactomedin-like domains
OPR Octicosapeptide repeat
OSTEOPONTIN OSTEOPONTIN
P P or trefoil or TFF domain
PA2 Phospholipase A2
PAC Motif C-terminal to PAS motifs (likely to contribute to PAS
structural domain)
PAH Pancreatic hormones / neuropeptide F / peptide YY family
PARATHYROID PARATHYROID
PAS PAS
PAX PAX
PBD P21-Rho-binding domain
PBPb Bacterial periplasmic substrate-binding proteins
PBPe Eukaryotic homologues of bacterial periplasmic substrate binding
proteins.
PDEc PDEc
PDGF Platelet-derived and vascular endothelial growth factors (PDGF,
VEGF) family
PDKc PDKc
PDZ Domain present in PSD-95, Dlg, and ZO-1/2.
PH Pleckstrin homology domain.
PHB prohibitin homologues
PHD PHD zinc finger
PHYTOc Phytochrome-like domain, homologous to Histidine Kinases
PI3K_C2 Phosphoinositide 3-kinase, region postulated to be contain C2 domain
PI3K_p85B PI3-kinase family, p85-binding domain
PI3K_rbd PI3-kinase family, ras-binding domain
PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3Kc Phosphoinositide 3-kinase, catalytic domain
PINT motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
PIPKc Phosphatidylinositol phosphate kinases
PKD Repeats in polycystic kidney disease 1 (PKD1) and other proteins
PLAc Cytoplasmic phospholipase A2, catalytic subunit
PLCXc Phospholipase C, catalytic domain(part); domain X
PLCYc Phospholipase C, catalytic domain (part); domain Y
PLDc Phospholipase D. Active site motifs.
PLEC Plectin repeat
POU POU
PP2Ac Protein phosphatase 2A homologues, catalytic domain.
PP2C_SIG Sigma factor PP2C-like phosphatases
PP2Cc Serine/threonine phosphatases, family 2C, catalytic domain
PRP Major prion protein
PTB Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
PTBI Phosphotyrosine-binding domain (IRS1-like)
PTI Plant trypsin inhibitors
PTN Pleiotrophin / midkine family
PTPc Protein tyrosine phosphatase, catalytic domain
PTPc_DSPc Protein tyrosine phosphatase, catalytic domain, overlap set
PTX Pentraxin / C-reactive protein / pentaxin family
PUA Putative RNA-binding Domain in PseudoUridine synthase and
Archaeosine transglycosylase
PWI PWI, domain in splicing factors
PWWP PWWP
PX PhoX homologous domain, present in p47phox and p40phox.
PXA Domain associated with PX domains
Pumilio Pumilio-like repeats
RA Ras association (RalGDS/AF-6) domain
RAB Rab subfamily of small GTPases
RAN Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
RAS Ras subfamily of RAS small GTPases
REC cheY-homologous receiver domain
RGS Regulator of G protein signalling domain
RHO Rho (Ras homology) subfamily of Ras-like small GTPases
RING Ring finger
RIO RIO-like kinase
RNASE_PANCREATIC Pancreatic ribonuclease
RRM_1 RNA recognition motif
RanBD Ran-binding domain
RasGAP GTPase-activator protein for Ras-like GTPases
RasGEF Guanine nucleotide exchange factor for Ras-like small GTPases
RasGEFN Guanine nucleotide exchange factor for Ras-like GTPases;
N-terminal motif
RhoGAP GTPase-activator protein for Rho-like GTPases
RhoGEF Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
S1 Ribosomal protein S1-like RNA-binding domain
S4 S4 RNA-binding domain
SAA Serum amyloid A proteins
SAM Sterile alpha motif.
SAM_PNT SAM / Pointed domain
SAND SAND
SAPA Saposin/surfactant protein-B
SAPB Saposins-like type B
SAR Sar1p-like members of the Ras-family of small GTPases
SCP SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains.
SCY Intercrine alpha family (small cytokine C-X-C) (chemokine CXC).
SEA Domain found in sea urchin sperm protein, enterokinase, agrin
SERPIN SERine Proteinase INhibitors
SET SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
SH2 Src homology 2 domains
SH3 Src homology 3 domains
SH3b Bacterial SH3 domain homologues
SNc Staphylococcal nuclease homologues
SO Somatomedin B -like domains
SOCS suppressors of cytokine signalling
SPEC Spectrin repeats
SPRY Domain in SPla and the RYanodine Receptor.
SR Scavenger receptor Cys-rich
START in StAR and phosphatidylcholine transfer protein
STYKc Protein kinase; unclassified specificity.
SURFACT_PALMYTOYL SURFACT_PALMYTOYL
SWIB SWI complex, BAF60b domains
S_TK_X Extension to Ser/Thr-type protein kinases
S_TKc Serine/Threonine protein kinases, catalytic domain
Sec7 Sec7 domain
ShKT ShK toxin domain
TACHYKININ Tachykinin family
TBC Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs.
TGFB Transforming growth factor-beta (TGF-beta) family
THAUMATIN Thaumatin family
THY Thymosin beta actin-binding motif.
TIMP Tissue inhibitor of metalloproteinase family.
TIR Toll - interleukin 1 - resistance
TNF Tumour necrosis factor family.
TNFR Tumor necrosis factor receptor / nerve growth factor receptor repeats.
TPR Tetratricopeptide repeats
TRANSFERRIN TRANSFERRIN
TRANSTHYRETIN TRANSTHYRETIN
TSP1 Thrombospondin type 1 repeats
TSPN Thrombospondin N-terminal -like domains.
TSPc tail specific protease
TUDOR Tudor domain
TY Thyroglobulin type I repeats.
TarH Homologues of the ligand binding domain of Tar
Tryp_SPc Trypsin-like serine protease
TyrKc Tyrosine kinase, catalytic domain
UBA Ubiquitin associated domain
UBCc Ubiquitin-conjugating enzyme E2, catalytic domain homologues
UBQ Ubiquitin homologues
UBX Domain present in ubiquitin-regulatory proteins
UTEROGLOBIN UTEROGLOBIN
VHP Villin headpiece domain
VHS Domain present in VPS-27, Hrs and STAM
VPS9 Domain present in VPS9
VWA von Willebrand factor (vWF) type A domain
VWC von Willebrand factor (vWF) type C domain
VWD von Willebrand factor (vWF) type D domain
WAP four-disulfide core proteins
WD40 WD40 repeats
WH1 WASP homology region 1
WH2 Wiskott Aldrich syndrome homology region 2
WNT1 WNT1
WR1 Worm-specific repeat type 1 present in yeast cell wall
WSC integrity and stress response component proteins
WW Domain with 2 conserved Trp (W) residues
XTALbg Beta/gamma crystallins
ZP Zona pellucida (ZP) domain
ZU5 Domain present in ZO-1 and Unc5-like netrin receptors
ZnF_A20 A20-like zinc fingers
ZnF_AN1 AN1-like Zinc finger
ZnF_C2H2 zinc finger
ZnF_C2HC zinc finger
ZnF_C3H1 zinc finger
ZnF_UBP Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
ZnF_ZZ Zinc-binding domain, present in Dystrophin, CREB-binding protein.
ZnMc Zinc-dependent metalloprotease
acidPPc Acid phosphatase homologues
alkPPc Alkaline phosphatase homologues
btg1 tob/btg1 family
cNMP Cyclic nucleotide-monophosphate binding domain
fCBD Fungal-type cellulose-binding domain
small_GTPase Small GTPase of the Ras superfamily; ill-defined subfamily